Z01 CP010119-02020 (Z01) | |||
---|---|---|---|
Title | Prospective study of farmers and their families (Agricultural health study) | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Alavanja, Michael | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $1,233,935 | Project Dates | 09/01/1992 - N/A |
Fiscal Year | 2008 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Alcoholism Research (5.0%) Biochemical Epidemiology (45.0%) Cancer (100.0%) Childhood Cancers (10.0%) Depression Research (10.0%) Diabetes (10.0%) Hematology (10.0%) Pesticides (100.0%) |
Bladder (5.0%) Breast Cancer (5.0%) Colon/Rectum (10.0%) Head and Neck (5.0%) Leukemia (10.0%) Lung (10.0%) Lymphoma (10.0%) Melanoma (5.0%) Multiple Myeloma (10.0%) Non Hodgkins Lymphoma (10.0%) Pancreas (5.0%) Prostate (10.0%) Skin (10.0%) Thyroid (5.0%) |
||
Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Endogenous Factors in the Origin and Cause of Cancer |
|||
Abstract | |||
The stimulus for this prospective investigation comes from the growing evidence that, despite a low mortality overall, farmers experience an excess of several cancers. These excesses have been observed in retrospective epidemiologic studies among agricultural workers in several countries. Excess cancers are observed for the lymphatic and hematopoietic system, connective tissue, skin, brain, prostate, stomach and lips. Several of these tumors (brain, NHL, multiple myeloma, and prostate) are also increasing in the general population in many of these countries. This suggests a common set of exposures may explain the high rates in farmers and rising rates in the general population. Farmers, their families, and other pest control workers may have contact with a variety of potentially hazardous substances including pesticides, solvents, fuels and oils, engine exhaust, dust and zoonotic viruses and other microbes. This cohort also includes all registered pesticide applicators in IA and NC and the spouses of the applicators who are farmers. The health effects of pesticide use are the primary focus of the study including both cancer and other chronic diseases. The influence of other farm exposures is also being evaluated. The focus of the phase III follow-up period is assessing etiology of cancer and non-cancer diseases and beginning mode-of-action studies. |